This lab test measures the levels of proteins called globulins in the fluid (serum) part of a blood sample. Globulins are a group of proteins within the blood. They are divided into three main groups: alpha, beta, and gamma. They are produced by the liver and the immune system. Globulins have multiple different functions; the group includes immunoglobulins, enzymes, carrier proteins and complement. Low level of globulin is a sign of several serious health conditions. Renal disease, hepatic dysfunction, celiac disease, inflammatory bowel disease (IBD), acute hemolytic anemia, agammaglobulinemia and hypogammaglobulinemia can cause the globulin levels to drop. This is also a sign that proteins taken in by the digestive system are not being broken down or absorbed properly. Increased level of globulin may indicate acute infection, bone marrow cancer and chronic Inflammatory Bowel disease, Rheumatic Arthritis and Systemic Lupus Erythematosis.